Question

1. Pulmonary drug delivery devices are designed to produce particles of what size (what range of particle diameters)?

2. List the 3 drug clearance mechanisms in the lung. In what region does each predominate and what cell types are involved in each mechanism?

3. Why is it important to breath slowly and deeply when using a pressurized metered dose inhaler? Your answer should include comments on particle velocity, mechanisms of particle deposition, and region of particle deposition.

4. Despite the above explanation for #9, why is it important to breath rapidly and forcefully when using a dry powder inhaler?

5. Describe the advantages a soft mist inhaler has over a pressurized metered dose inhaler.

Answer 1

1) particle size < 5um have greatest possibility of deposition in the lung, and particle with <2 um can reach up to alveoli, the partical wih 1um are largely exhaled out as they remain suspended in the air during respiration.

2) asthma- those who have onset in childrens- , wastern regions epithelial cells and smooth muscles

chronic obstructive pulmonary disease- old age people: neutrophils macrophages, T-lymphocytes, and dendritic cells

cystic fibrosis- myoepithelial cells, middle eastern regions beta- adrenergic- insensitive cell, beta - adrenergic sensitive cell .

3) soft mit inhaler: it creates a could of medicine that you inhale without the help of a propellant