Burnt patient are severely dehydrated due to excessive loss of interstitial fluid and intracellular fluids due to burn. This severe dehydration decreases reh blood volume and blood pressure. This in turn results in causes decrease in GFR. This stimulates release of renin, which, through the renin–angiotensin system, causes constriction of the efferent arterioles, which ultimately increases hydrostatic pressure in the glomerulus. The process triggered by the macula densa helps keep the GFR fairly steady in response to varying artery pressure.
In this way kidney respond to maintain GFR and blood pressure.
Also hypoxia due to low perfusion stimulates the release of Erythropoietin to increase red cell count to fulfil the oxygen demand.
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