Question

On which of the following genomic regions would you expect to find hypermethylation, relative to other regions of the genome? (multiple answers possible)

- Tumor suppressor genes in tumor cells

- The Barr body X chromosome in female mammals

- The X chromosome in male Drosophila

- Oncogenes in tumor cells

- Repetitive regions of the genome that harbor transposable elements

Answer 1

On which of the following genomic regions would you expect to find hypermethylation, relative to other regions of the genome? (multiple answers possible)

Answer: Tumor suppressor genes in tumor cells.

Oncogenes in tumor cells.

DNA hypermethylation refers to the addition of a methyl group by the action of an enzyme called methyltransferase enzymes to the cytosine residues at 5′ position of the pyrimidine ring of CpG islands through an epigenetic mechanism is found to be the one of the causes of tumorigenesis. The gene inactivation of tumor suppressor genes is due to the hypermethylation of CpG islands located in the promoter regions which is found to be present in almost all tumor type. In addition, it is observed that the oncogene promotors are always hypermethylated in cancer cells.