Question

Which of the following situations would you expect to lead a fertilized egg to develop into an adult with a male-typical (or almost male-typical) biological sex phenotype, including the development of testes? Assume in all cases that the sex chromosomes contain only the genetic loci that are typically found on those chromosomes. Select ALL that are correct.

Multiple answers:You can select more than one option

A Klinefelter's Syndrome (caused by nondisjunction - sex chromosome genotype XXY).

B Turner Syndrome (caused by nondisjunction - sex chromosome genotype X).

C XYY Syndrome (caused by nondisjunction - sex chromosome genotype XYY).

D Triple X Syndrome / Trisomy X (caused by nondisjunction - sex chromosome genotype XXX).

E Congenital Adrenal Hyperplasy (sex chromosome genotype XX - caused by excessive production of androgen hormones by the adrenal glands once they have developed).

Answer 1

There are two conditions in which the fertilized egg will develop into normal male. These are-

1. XYY syndrome.

2. Congenital adrenal hyperplasia.

In XYY syndrome, the male has extra pair of Y chromosome. The male has normal testes development and male characters are intact.

In congenital adrenal hyperplasia, the cortisol hormone is less produced from adrenal gland. This cause hyperplasia of gland and more androgen is produced from gland. The male characters and testes remain normal.

Turner's syndrome and Triple X syndrome are seen in females. So the fertilized egg with these two syndrome will turn into female not male.

in case of Klinefelter's syndrome, the testes remain undescended. Female characters also develop in these individual.