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A couple is normal but each has one parent with Wilson’s disease. The disease is autosomal...

A couple is normal but each has one parent with Wilson’s disease. The disease is autosomal recessive. What is the probability that AT LEAST ONE of their TWO children will have the disease?
Math   Statistics-And-Probability   
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Answer #1

It is given that Wilson's disease is an autosomal recessive condition. The parents are genetic carriers of the wilson's disease. They both possess the ability to pass the mutant gene to thèir children. So is a 25% probability that the child will have disease as both parents are genetic carriers of Wilson's disease.

So there is one in four chance or 25 % chance for both the children with two normal genes and 50% chance that the child will be a carrier without the disease. So, the probability that atleast one of their two children will have the disease is 25%.

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