Question

Sickle cell anemia is an autosomal recessive disease. A man and a woman are both heterozygous for the mutant gene. They have two children and one has the disease. What are the chances their next child will have the disease?

100%
		75%
		50%
		25%

Answer 1

Answer- 25%

Sickle cell anemia is an Autosomal recessive disorder. The affected individual must carry both recessive alleles to be affected . If an individual carries one copy of recessive Allele and one copy of dominant alleles ,that Individual is a carrier , that is appears normal with no sickle cell anemia but transmits the gene to bext generation . A normal Individual will carry both dominant alleles .

Though an individual is normal in both Heterozygous and homozygous dominant genotypes.

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