Question

. A man’s grandfather has galactosemia, a rare autosomal recessive disease caused by the inability to...

. A man’s grandfather has galactosemia, a rare autosomal recessive disease caused by the inability to process galactose, leading to muscle, nerve, and kidney malfunction. The man married a woman whose sister had galactosemia. The woman is now pregnant with their first child.

b. What is the probability that this child will have galactosemia?

c. If the first child does have galactosemia, what is the probability that a second child will have it?

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Answer #1

The probability of the man getting the defected allele is 1/4

1/2 probability of the child being a male and another 1/2 for him to acquire the disease allele

The woman must be atleasr a carrier if her sister suffered from the disease i.e. the probability of her having the allele is 1/2

The probability For both these to produce a child with the disease is 1/4*1/2=1/8

C. The probability of the disease occurrence will remain the same irrespective of the order and sex.

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