Question

When dopamine (subtype 2) receptors are blocked in this pathway (system), it is evident by EPS....

When dopamine (subtype 2) receptors are blocked in this pathway (system), it is evident by EPS.

A.

Mesocortical
B.

Tuberoinfundibular
C.

Nigrostriatal
D.

Mesolimbic
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Answer #1

Extrapyramidal side symptoms (EPS) are motor dysfunction characterized by tremor, akathesia, dystonia, Tardive dyskinesia, etc. and it is mainly occur due to the side effects of antispsychotic drugs when drugs blocks dopemine receptor

Nigrostriatal system contain more dopamine and this pathway involved in planned motor activity (voluntary motor actions). Blocking of D2 receptors (dopamine receptors) in Nigrostriata pathway causes extrapyramidal symptoms (involuntary motor actions)

Answer is- C. Nigrostriatal

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