Question

Inward synaptic current is effectively blocked through NMDA receptors unless the postsynaptic cell is depolarized in order to:

	A.	generate nitric oxide
	B.	activate adenylate cyclase
	C.	release serotonin
	D.	expel blocking magnesium ions (Mg++) from the pore of the channel
	E.	close the AMPA receptors in a voltage-dependent manner

Drugs like Prozac, a widely prescribed SSRI class of drug for depression, work by:

	A.	blocking serotonin receptors
	B.	up-regulating serotonin receptor expression
	C.	blocking the re-uptake of serotonin
	D.	activating GABA receptors
	E.	blocking dopamine receptors

Answer 1

Answer 1- D) expel blocking magnesium ions( Mg++) from the pore of the channel.

Reason- Inward synaptic current is effectively blocked through NMDA receptors & the postsynaptic cell is depolarized, resulting in Binding of glutamate. The Na+ and Ca++ influx occurs, thus Mg+ blockade ion will be expelled and channel will open.

Answer 2- C) blocking the re-uptake of serotonin.

Reason- Prozac has an antidepressant effect. It inhibits serotonin re-uptake at the synapse by binding to pump on the neuronal membrane to enhance neurotransmission.