Damilola Anderson is a 62-year-old woman. She was travelling with her husband to see their children and grandchildren following Queensland’s eased COVID-19 restrictions. Damilola developed generalised abdominal pain, fever, and vomiting and was admitted to the CQUniversity Hospital (CQUH). After being assessed in the emergency department (ED), Damilola was diagnosed with acute appendicitis. A broad-spectrum antimicrobial, ceftriaxone was commenced immediately and she underwent a non-elective appendectomy. As part of the treatment plan, paracetamol is charted as regular analgesia, oxycodone as prn analgesia and ondansetron as a once only order for nausea/vomiting. Damilola has a history of severe anaphylaxis to penicillins. On day 2 post-op care on a surgical ward, the medical team reviewed Damilola and ceased ceftriaxone. They commenced Damilola on ampicillin. Nurse B administered ampicillin as per the medication order and Damilola developed anaphylaxis. Nurse B activated a medical emergency team (MET) call and the MET moved Damilola to the intensive care unit for further care.
The medical team at the hospital changed the antimicrobial to a broad-spectrum (ampicillin) for Damilola as part of the appendicitis treatment plan.
1. Discuss the pharmacokinetics (absorption, distribution, metabolism, excretion) of penicillins.
Include in your response:
a) Absorption: • Clarify how penicillins can be absorbed, i.e. routes of administration. • Explain the difference in the onset of action between administering penicillins via oral and intravenous routes. • Discuss which is the most appropriate route to administer this antimicrobial to Mrs Anderson and provide an evidence-based rationale for your decision.
b) Distribution: After absorption, some of the penicillins, binds to plasma proteins. • Discuss your understanding of ‘protein binding’.
c) Metabolism: • Describe the half-life of penicillins
d) Excretion: • Briefly discuss the organ responsible for the excretion of penicillins and the importance of monitoring its function. • Identify the renal clearance of penicillins and your understanding of this phrase.
2. Discuss the pharmacodynamics (mechanism of action) of penicillins.
• Discuss how penicillins work to manifest its pharmacological effects.
• Discuss two (2) major side effects and/or adverse reactions of penicillins specifically relating these effects to Mrs Anderson.
1. Pencillin is a group of antibiotics derived originally from common moulds known as pencillium moulds which includes pencillin G( intravenous use), pencillin V ( use by mouth) procaine pencillin and benzathine pencillin( intramuscular use)
Pencillin antibiotics are the first medications to be effective against many bacterial infections caused by staphylococci and streptococci.
ABSORPTION:
DISTRIBUTION
METABOLISM
EXCREATION
2. MECHANISM OF ACTION OF PENCILLINS
ADVERSE EFFECTS
Get Answers For Free
Most questions answered within 1 hours.