Question

Phosphorylation of glucose by hexokinase illustrates which kind of enzyme reaction mechanism? (a) covalent catalysis (b)...

Phosphorylation of glucose by hexokinase illustrates which kind of enzyme reaction mechanism?

(a) covalent catalysis

(b) proximity and positioning

(c) general acid-base catalysis

(d) metal ion catalysis/redox

(e) none of the above

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Answer #1

metal ion catalysis/redox

ATP forms a complex with magnesium (II) ion and glucose binds to hexokinase. The magnesium-ATP complex then binds with the hexokinase-glucose complex and forms an intermediate. The hydroxyl group on the terminal phosphoryl group of the ATP molecule nucleophilically attacks carbon 6 on glucose. This produces glucose-6-phosphate still bound to hexokinase and ADP still in complex with magnesium ion Glucose-6-phosphate and the magnesium-ADP complex leave hexokinase.

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