Question

Which of the following are true?

I. All enzymes are highly specific for the reactions they catalyze.

II. Prosthetic groups are loosely associated with the polypeptide chain of an enzyme

III. When comparing types of catalysis, the proximity effect provide the largest rate enhancement

IV. Acid-base catalysis involves proton transfers.

A. I, II, III and IV

B. I, III

C. I

D. III

E. IV

Appreciate the help!

Answer 1

Answer: C.I only true statement

True: I. All enzymes are highly specific for the reactions they catalyze.

False: II, III, and IV are incorrect

II. Prosthetic groups are loosely associated with the polypeptide chain of an enzyme

III. When comparing types of catalysis, the proximity effect provide the largest rate enhancement

IV. Acid-base catalysis involves proton transfers.

The other possible true option will be - If an enzyme-catalyzed reaction requires a group with a low pK to be deprotonated and a group with a higher pK to be protonated, the pH vs. rate curve will have a peak in the middle of the two pK values. Acid-base catalysis may be accomplished by charge delocalization, so solely Acid-base catalysis involves proton transfers is incorrect statement.

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