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FAD is a stronger oxidant than NAD+; FAD has a higher standard reduction potential than NAD+....

FAD is a stronger oxidant than NAD+; FAD has a higher standard reduction potential than NAD+. Yet in the last reaction of the pyruvate dehydrogenase complex, FADH2 bound to E3 is oxidized by NAD+. Explain this apparent paradox.

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Answer #1

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The redox potential of flavin,which does not dissociate from it's enzyme,depends on it's protein environment.In lipoamide dehydrogenase,it's redox potential is held more negatice than in other flavin dehyogenase s so that electrons can be passed onto NAD+ under physiological conditions.

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