Question

What is the nature of DNA sequences that do not favor formation of nucleosomes?

What is the nature of DNA sequences that do not favor formation of nucleosomes?

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Answer #1

ANSWER :

The nucleosomes are small bundles formed when chromatin (DNA sequence) wraps around specific histone proteins and appear like beads in a string, which help to package the long DNA in a compact form that fits into a cell nucleus. However, the DNA sequence is a critical determinant for how the nucleosomes rotationally positioned, because for optimal nucleosome formation, more bendable sequences of DNA are required in contact with histones (or exact positioning of histone octamer with respect to approx. 10 bp helical repeats).

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