Question

What can SNPs do to wild-type sequences of DNA if they have mutations in base pairing?

Answer 1

Ans. Single nucleotide polymorphisms (SNPs) represents difference in a single nucleotide in DNA. If SNPs affect base pairing there will not be hydrogen bonding between the mutated nucleotide and its opposite base on the complementary strand of DNA. It will affect the stable three dimentional structure because hydrogen bonding keeps the two complentary strands of DNA tightly interwinded to each other. This change in stable structure of DNA may affect binding of many DNA binding proteins and hence will affect gene expression process.