Question

During the process of apoptosis which protein activates the adaptor protein?

Select one:

- Bax

- Bcl-2

- apoptosome

- Cytochrome C

- Procaspase-9

Answer 1

Apoptosome is the multi-protein complex which activates the adaptor protein during the process of apoptosis.

Bcl-2 is a family of apoptosis regulator proteins. Bax is Bcl-2 associated X protein. Bcl-2 is anti-apoptosis regulator protein and Bax is pro-apoptosis regulator protein and they influence the mitochondrial pathway. Bax being a pro-apoptotic protein leads to the release of cytochrome c.

Release of cytochrome c, triggers the formation of the quaternary protein structure known as apoptosome which activates inactive initiator protein procaspase-9. Caspase-9 is the intrinsic apoptosis initiator or adaptive protein with a single death fold called CARD or caspase binding domain.

It is this domain which allows further interaction by binding and cleaving for further activation of the executionor caspase-3 which results in cell death by degradation of all proteins.