Question

A proto-oncogene can become an oncogene by mutations that result in all the following EXCEPT ____.

Select one:

unregulated protein

hyper expression

inactivating

gene amplification

hyperactive protein product

Answer 1

Answer:

(iv) inactivating

Unregulated protein expression may result in formation of oncogenes because the hyper activation of a protein near to the proto oncogene may enhance the expression of proto oncogene and convert it to oncogene.

As explained above, the hyper expression of any region nearer to proto oncogene may eventually lead it to its conversion to oncogenes.

Gene amplification may lead to hyper expression of that protein and lead to formation of oncogenes.

Hyperactive protein products may upregulate the expression of proto oncogenes and convert them to oncogenes.

However in case of inactivation of proto oncogene, the gene can not express. There may be other problems related to that. But there will be no cancer caused due to uncontrolled cell division. So option (iv) is the correct option.

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