Question

Provide ways in which a toxic protein could be therapeutically targeted to become

non-functional.

Answer 1

When a protein become misfolded or gets damaged it is toxic in nature and cause disease to humans . To make this toxic protein non functional the enzyme protease plays an important part it makes the protein to become non functional by making it in form of polypeptides and smaller units , the proteins are targets to degradation by covelant attachment of a tag that consists of several copies of the small protein ubiquitin. And protease work on these proteins now and denaturation occurs .