Question

Which type of intersex condition is guevedoce? Describe the phenotypes of these individuals from birth to after puberty, their sex chromosome combination, and the genetic mutation they have.

Answer 1

Guevedoces", literally means "penis at twelve". Guevedoce is a kind of intersex where when a human born, it seems that he is female, but at the of 12 , he starts to develop penis. Upto puberty they look like a female with vagina. At the age of puberty, the testes starts to develop and testicles descended from the abdomen.

The person who are Guevedoces", are genetically male which means they have one X chromosome and one Y chromosome.

The main cause of this in their tissue Testosterone is unable to be converted to dihydrotestosterone, or DHT which is the active form of testosterone and causes the development of male characters. 5 alpha reductase is the enzyme which is responsible for conversion of testosterone to dihydrotestosterone. Deficiency of 5 alpha reductase enzyme cause Guevedoces. It has been demonstrated that mutation in the SRD5A2 gene cause 5-alpha reductase deficiency.