Question

Which of the six B6 vitamers will likely not cross the brain-blood barrier and why? Which...

Which of the six B6 vitamers will likely not cross the brain-blood barrier and why?

Which of the six B6 vitamers would you recommend for a patient with a defective PNP oxidase in the brain and why?

why large excess of B6 can lead to toxic effect, and why deficiency can lead to several neurological diseases.

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Answer #1

There are several B6 vitamers:

1. Pyridoxal 5?-phosphate (PLP)

2. Pyridoxamine (PM)

3. Pyridoxamine 5?-phosphate (PMP)

4. Pyridoxine (PN)

5. Pyridoxine 5?-phosphate (P5P)

6. Pyridoxal (PL)

Out of these Pyridoxal 5?-phosphate (PLP) is can not pass blood brain barrier because it is the water soluble and it reacts with the primary amines to form schiff base. It is cofactor which is used in the biosynthesis of serotonin.

2. Pyridoxin is best vitamin because it is water soluble and act as cofactor for the synthesis of serotonin and dopamine.

3.Excess Vitamin B-6 leads to toxic effect because it act as cofactor in the biosynthesis of serotonin which is (5-Hydroxy typtamine). It is selctive reuptake inhibitor in antidepresents. So due to deficiency it blocks the synthesis of 5-HT and leads to neurological diseases anxiety and depression. Excess amount of vitamin B-6 leads to nerve damage.

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