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Why aren't all self reactive lymphocytes elkminated during central tolerance?

Why aren't all self reactive lymphocytes elkminated during central tolerance?
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The immune system doesn't know what peptides are self and which are non-self. Thymic selection can eliminate some self reactive T cells but apparently not all of them. The negative selection process will kill off T or B cells that bind self really well but the T or B cells for tissue specific antigens get through. Those have to be controlled by peripheral tolerance mechanisms ,to ensure that T and B cells are not self-reactive once they leave primary lymphoid organs.

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