Question

In this lesson, we discussed mechanisms of central and peripheral tolerance for T cells. Imagine a self-reactive T cell that has not undergone clonal deletion in the thymus (that is to say, it has escaped central tolerance). If it encounters self antigen in the absence of an infection or inflammation, what will happen to this self-reactive T cell? (select two answers)

The T cell undergoes clonal expansion.

The T cell gains effector functions.

The T cell undergoes apoptosis.

The T cell becomes activated.

The T cell becomes anergic.

Answer 1

Answer=The following happens to self-reactive T cell

The T cell undergoes apoptosis.

The T cell becomes anergic.

explaination-

peripheral tolerance is the second branch of immunological tolerance .It takes place in immune periphery.

Mechanism of peripheral tolerance include direct inactivation of effector T cells by either clonal deletion ,Induction of anergy.and activated induced cell death i.e.apoptosis.

T-cells can be made non-responsive to antigens presented if the T-cell engages an MHC molecule on an antigen presenting cell (signal 1) without engagement of costimulatory molecules (signal 2).