Question

Which of the following statements about induction or maintenance of T cell tolerance is NOT true?

	a.	Peripheral T cell tolerance to an antigen may be induced by persistent and repeated stimulation of lymphocytes by that antigen in tissues.
	b.	Peripheral T cell tolerance results when T cells recognize antigen in the setting of an innate immune response to the antigen.
	c.	Peripheral T cell tolerance to some antigens is induced when mature T cells recognize antigen and bind B7-1 or B7-2 via the inhibitory CTLA-4 receptor.
	d.	Peripheral T cell tolerance results when mature naive T cells recognize antigens without adequate B7-1– or B7-2–mediated costimulation.
	e.	Central tolerance is induced when immature developing T cells in bone marrow or thymus encounter self-antigens.

Answer 1

Answer 1)  following statements about induction or maintenance of T cell tolerance are NOT true?

b) Peripheral T cell tolerance results when T cells recognize antigen in the setting of an innate immune response to the antigen.

c) Peripheral T cell tolerance to some antigens is induced when mature T cells recognize the antigen and bind B7-1 or B7-2 via the inhibitory CTLA-4 receptor.

Reason - Since there is no such requirement for the setting of an innate immune response in case of peripheral T cell tolerance. also, there is a requirement of B7-1- or B7-2-2 mediated costimulation to keep T cell tolerance under control.