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How is it possible to NOT observe transmembrane proteins on top of cell surfaces?

How is it possible to NOT observe transmembrane proteins on top of cell surfaces?

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Answer #1

Answer. There are various reasons to it:

  • They show alpha helix and beta sheet in their structure which is not the best way to accommodate on the outer or the inner surface of the plasma membrane.
  • Usually, their N-terminal faces the cytosol and C-terminal faces the cell outer and alpha helix and beta pleated sheet embedded in the membrane. This is the feasible structure for them along with their location because this way they can carry on the transport of ions along either side of the membrane. As majorly transmembrane proteins act as channels and helps in transportation.
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