Question

What mutations of serine (S), threonine (T), and tyrosine (Y) are used to mimic phosphorylation?

What mutations of serine (S), threonine (T), and tyrosine (Y) are used to mimic phosphorylation?

Homework Answers

Answer #1

Phosphomimetics are mutations of serine (S), threonine (T), and tyrosine (Y) are used to mimic phosphorylation. These are amino acid substitutions that mimic a phosphorylated protein, thereby activating or deactivating the proteins.

Phosphorylation is a common mode of activating or deactivating a protein for their regulation within cells. proteins are usually modified at serine, tyrosine and threonine amino acids by adding a phosphate group.

Aspartic acid is chemically similar to phospho-serine. When an aspartic acid replaces a serine, it is a phosphomimetic of phospho-serine and can make the protein always in its phosphorylated form. This chemical similarity can be exploited in cancer study.

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