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What mutations of serine (S), threonine (T), and tyrosine (Y) are used to mimic phosphorylation?

What mutations of serine (S), threonine (T), and tyrosine (Y) are used to mimic phosphorylation?

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Answer #1

Phosphomimetics are mutations of serine (S), threonine (T), and tyrosine (Y) are used to mimic phosphorylation. These are amino acid substitutions that mimic a phosphorylated protein, thereby activating or deactivating the proteins.

Phosphorylation is a common mode of activating or deactivating a protein for their regulation within cells. proteins are usually modified at serine, tyrosine and threonine amino acids by adding a phosphate group.

Aspartic acid is chemically similar to phospho-serine. When an aspartic acid replaces a serine, it is a phosphomimetic of phospho-serine and can make the protein always in its phosphorylated form. This chemical similarity can be exploited in cancer study.

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