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Phosphorylation is a commonly used molecular switch during signal transduction. Proteins are only phosphorylated on tyrosine,...

Phosphorylation is a commonly used molecular switch during signal transduction. Proteins are only phosphorylated on tyrosine, serine, or threonine residues. Why do you think this is?

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Ans) Phosphorylation plays an essential role in post translational modification and during signal transduction.Phosphorylation mainly occurs on tyrosine,serine and threonine residues because of the presence of OH (Hydroxyl group) group on these amino acids.Kinases are responsible for the addition of phosphate groups to the proteins and phosphatase are responsible for the removal of phosphates.Phosphorylation can either activate the protein or inactivate too (For example phosphorylation of Rb protein will inactivate it and the E2F transcription factor will be released from the Rb and the E2F will now start the cell cycle.

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