Question

what cells typically express CCR5?

What cells typically express the ligand for CCR5?

Answer 1

CCR5:Chemokin receptor 5 is expressed on various cells like macrophages, memory T cells and dendritic cells in the immune system; epithelium, endothelium, vascular smooth muscle and fibroblasts; microglia, astrocytes and neurons in the central nervous system.

Natural ligands for CCR5 are

i) Monocyte Chemotactic Protein Two (MCP-2)

ii) Regulated upon activation, normal T-cell expressed, and secreted (RANTES)

iii) Macrophage inflammatory protein one alpha (MIP1-α)

iv) Macrophage inflammatory protein one beta (MIP-1β)