Question

In the following signal pathway, which protein can you activate to turn ON the downstream response? A --| B --| C --> D --> E --| Downstream response

A

B

C

D

E

Answer 1

In the pathway,

A --| B --| C --> D --> E --| Downstream response

1. If A is activated, A inhibits the function of B. As a result B cannot inhibit C. C will stimulate D and D will activate E which in turn inhibits the Downstream response.
2. If C is activated, C will stimulate D and D will activate E which in turn inhibits the Downstream response.
3. If D is activated, D will activate E which in turn inhibits the Downstream response.
4. If E is activated, E inhibits the Downstream response.
5. If B is activated, B inhibits the activity of C. As a result of this D cannot be stimulated and the activity of E gets blocked. This results in free downstream processing.

Therefore, the answer is B.

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