Question

As a result of a mutation that disrupts the nuclear localization signal of a protein, the...

As a result of a mutation that disrupts the nuclear localization signal of a protein, the protein will now be.....

A. be translocated into the ER

B. be ubiquitinated and degraded.

C. remain in the cytosol

*** I think this is the answer

D. be exported from the nucleus

E. bind tightly to the nuclear pore

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Answer #1

Answer: Choice C

Explanation: A newly synthesized protein or nascent protein is transiently localized in the rough endoplasmic reticulum. The nascent protein contains a leader sequence which helps it to transit to the desired location, such as mitochondria, golgi apparatus, nucleus etc. However, if this leader sequence is degraded in the nascent protein, it would not be able to transit tot he desired location and stuck inside the endoplasmic reticulum. However, since endoplasmic reticulum does not contain any storage space, this nascent protein would be released in the cytosol. Thus, the loss of leader-sequence would result in localization of the nascent protein in the cytosol.

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