Question

hello, I already asked this but I would rather see this in a table that compares between mhci mhcii.

so I would apreciate a table of "MHCI and MHCII antigen processing" that says exactly what kind of epitiopes attach, what chaperons help stabilize and where, if TAP moves MHCI to the ER who moves MHCII to there? and anything you feel helpful to understand these reactions.. please in a table so I can compare better.. thanks!

Answer 1

.MHC I	MHC II
Involves endogenous pathway	Involves exogenous pathway
In this cellular peptide fragments are presented on the cell surface.	In this peptide derived from proteins that have been endocytosed are presented.
CD8+ T cells recognize the peptides.	CD4+ T cells recognize the peptides.
Peptides are transported from cytosol to ER by Transporter associated with Antigen Processing (TAP).	Since peptides are endocytosed therefore they reach ER via endocytosis so no special transporter is needed.
Calnexin, calreticulin, ERp57, and Binding immunoglobulin protein (BiP) are the chaperones which promotes proper folding of MHCI in ER.	The chaperone called as invariant chain (I chain) or CD74 promotes association of MHCII subunits.