Question

When it comes to inherited disorders, what potential roles do genomic imprinting and certain organelles play? Be very specific in your answer.

Answer 1

Genomic imprinting controls the expression of some genes involved in the development of mammalian embryos. It also lead to allelic exclusion that is in some cases only paternal allele of imprinted gene is expressed and in some cases only maternal allele is expressed , so if there would be a mutation in expressed copy of allele then it will lead to a disorder. Here organelle refers to mitochondrial as mitochondria is inherited from mother so it lead to maternal effect and if it is defected in mother then it will pass on to the progeny and show its phenotype regardless of its genotype.