Put in the correct order the following steps of the Ras-MAPK signaling pathway downstream of a receptor tyrosine kinase.
- 1. 2. 3. 4. 5. 6. 7. 8. 9.
MAP kinase-kinase phosphorylates MAP kinase (erk).
- 1.
2. 3.
4. 5.
6. 7.
8. 9.
Phosphorylated tyrosine residues on the receptor recruit Grb2 through its SH2 domain.
- 1.
2. 3.
4. 5.
6. 7.
8. 9.
MAP kinase phosphorylates & activates downstream molecules such as transcription factors & cytoskeletal proteins.
- 1.
2. 3.
4. 5.
6. 7.
8. 9.
Kinase domains on the receptor cross-phosphorylate the cytoplasmic tail of the partner.
- 1.
2. 3.
4. 5.
6. 7.
8. 9.
MAP kinase-kinase-kinase phosphorylates MAP kinase-kinase (mek).
- 1.
2. 3.
4. 5.
6. 7.
8. 9.
SOS activates Ras.
- 1.
2. 3.
4. 5.
6. 7.
8. 9.
Grb2 uses its SH3 domain to recruit the GEF, Sos.
- 1.
2. 3.
4. 5.
6. 7.
8. 9.
Ligand binding results in dimerization of the enzyme-linked receptor.
- 1.
2. 3.
4. 5.
6. 7.
8. 9.
Ras activates MAP kinase-kinase-kinase (raf).
1. Ligand binding results in dimerization of the enzyme-linked receptor.
2. Phosphorylated tyrosine residues on the receptor recruit Grb2 through its SH2 domain.
3. Grb2 uses its SH3 domain to recruit the GEF, Sos.
4. SOS activates Ras.
5. Kinase domains on the receptor cross-phosphorylate the cytoplasmic tail of the partner.
6. Ras activates MAP kinase-kinase-kinase (raf)
7. MAP kinase-kinase-kinase phosphorylates MAP kinase-kinase (mek).
8. MAP kinase-kinase phosphorylates MAP kinase (Erk).
9. MAP kinase phosphorylates & activates downstream molecules such as transcription factors & cytoskeletal proteins.
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