Question

The large increases in cancer incidence observed with certain types cancer in immune compromised individuals indicates that human tumor cells highly immunogenic. A) True B) False

Answer 1

A) True

Explanation :

Human tumor cells highly immunogenic because It is now widely accepted that human tumours are immunogenic, meaning that they elicit adaptive immune responses in vivo. These responses are mostly mediated by T cells. Spontaneous anti-tumour T cell responses occur frequently in cancer patients, and analyses of these patients led to the molecular identification of tumour antigens that are recognized by T cells. The presence of T cells within tumours, which is often associated with a more favourable clinical outcome, is probably a consequence of these spontaneous responses. The immunogenicity of a tumour depends on its antigenicity and on several other immunomodulatory factors that are produced either by tumour cells or by host cells in the tumour microenvironment. Many immunomodulatory mechanisms operate in tumours. Most of them inhibit anti-tumour immunity.