Question

MADSNGTITVEELKKLLEQWNLVIGFLFLTWICLLQFAYANRNRFLYIIKLIFLWLLWPVTLACFVLAAV YRINWITGGIAIAMACLVGLMWLSYFIASFRLFARTRSMWSFNPETNILLNVPLHGTILTRPLLESELVI GAVILRGHLRIAGHHLGRCDIKDLPKEITVATSRTLSYYKLGASQRVAGDSGFAAYSRYRIGNYKLNTD HSSSSDNIALLVQ

1.  Identify one stretch of a possible transmembrane region on this protein sequence.

Answer 1

This is the stretch of amino acid sequence which consists of hydrophobic and neutral amino acids which include continous stretch of 45 amino acids as cell membrane thicknes is 75A and transmembrane protein is made up of alpha helical structure.

One turn having 3.6 amino acid and size is 5.4 A

So no. Of amino acids required to pass 75A cell membrane are =( 75/5.4) x3.6= 50 amino acids

FLYIIKLIFLWLLWPVTLACFVLAAVYRINWITGGIAIAMACLVGLMWL

Green color shows hydropbic amino acid and blue color basic amino acids black color nuetral amino acids.

Hope it's clear .thanks