Question

Which immunoglobulin light chain rearranges first?

Answer 1

Answer : Immunoglobulin  light chain protein can be encoded by the kappa (κ) or lambda (λ) genes.Each Cλ gene is located 3′ of a respective Jλ gene and light chain genes do not include D region loci and greater than 90% of murine B cells express κ protein. However, the proportions of human κ and λ proteins are more equivalent, with approximately 60% of human B cells expressing κ light chain protein.So, from the above explanation we can say for Immunoglobulin light chain lambda(λ) gene rearrangement can precede kappa(κ) gene