Question

1. What is meant by allelic exclusion with regard to antibody heavy or light chain genes?...

1. What is meant by allelic exclusion with regard to antibody heavy or light chain genes? Explain how this this is accomplished. What happens to B cells which fail to produce functional antibody heavy chain genes from either of their original two copies of the gene?

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The allelic exclusion control ensures that each B cell expresses only one type of binding site because an antibody binding site is determined by the combination of a particular heavy and light chain. If expression of the Ig alleles was not regulated each B cell would express several combinations of the two different heavy and light chains and thus express a variety of antigen specificities. Such unregulated B cells would not be able to mediate a specific immune response.

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