Question

1. What is meant by allelic exclusion with regard to antibody heavy or light chain genes?...

1. What is meant by allelic exclusion with regard to antibody heavy or light chain genes? Explain how this this is accomplished. What happens to B cells which fail to produce functional antibody heavy chain genes from either of their original two copies of the gene?

Science   Biology   
0 0
Add a commentTranscribed image text
Next >

Homework Answers

Answer #1

The allelic exclusion control ensures that each B cell expresses only one type of binding site because an antibody binding site is determined by the combination of a particular heavy and light chain. If expression of the Ig alleles was not regulated each B cell would express several combinations of the two different heavy and light chains and thus express a variety of antigen specificities. Such unregulated B cells would not be able to mediate a specific immune response.

0 0
Know the answer?
Your Answer:

Post as a guest

Your Name:

What's your source?

Earn Coins

Coins can be redeemed for fabulous gifts.

Log In

Sign Up

Not the answer you're looking for?
Ask your own homework help question
Similar Questions
6. Red-green color blindness occurs in about 8% of males and .4% of females. Many genes...
6. Red-green color blindness occurs in about 8% of males and .4% of females. Many genes contribute to Red-green colorblindness and most of these are sex-linked, which is the reason for the disparity in the frequency between males and females. Call the allele that encodes a functional product "+" and the allele that encodes a non-functional product "=". Why is Red-green color blindness more fequent in males? a.   because males inherit only a single X chromosome, which means that inheriting...
35: the identification and study of genes important for the cell cycle in budding yeast has...
35: the identification and study of genes important for the cell cycle in budding yeast has provided great insight into our understanding of the unregulated cell cycle in cancer cells. Why is budding yeast such a useful model sysetm for studying the cell cycle? a. As budding yeast progress through the cell cycle, they naturally express a GFP-tagged protein that is visible by fluorescence microscopy b. it is easy to visualize yeast by scanning the electron microscopy, which is helpful...
1.In the chart: A B C D +/+ 100% functional protein watery no disease +/- 50%...
1.In the chart: A B C D +/+ 100% functional protein watery no disease +/- 50% functional protein intermediate no disease -/- 0% functional protein thick disease What is in column A? Different genes Different phenotypes Different genotypes Different loci Different proteins 2. let's say SLC2A4 (encoding the insulin-dependent glucose transporter GLUT4) has two alleles: + (which encodes a functional product) and - (which encodes a non-functional product). If GLUT4 expression is necessary to not have diabetes, which of the...
If AaBbCcDd is mated to AaBbCcDd (no gene interactions among all genes), what is the probability...
If AaBbCcDd is mated to AaBbCcDd (no gene interactions among all genes), what is the probability that the offspring will have either the phenotype AaB_CcDD or the genotype AAbbCcD_? (assuming complete dominance for genes) (Show procedure, NO score for direct result) A mouse sperm of genotype a BCDE fertilizes an egg of genotype a bcDe. What are all the possibilities for the genotypes of (a) the zygote and (b) a sperm or egg of the baby mouse that develops from...
A) Iron(II) forms what is termed a “charge transfer complex” with the 1,10-phenanthroline. What is meant...
A) Iron(II) forms what is termed a “charge transfer complex” with the 1,10-phenanthroline. What is meant by this term and why are such complexes highly colored (i.e. how/why is the absorption of light so favored at their characteristic wavelength)? (Note: your textbook specifically discusses the iron-1,10-phenanthroline complex; be careful – it is an exception to some generalities about charge transfer complexes.) (0.5) 3 B) Iron(III) also forms a complex with the phenanthroline ligand; explain why it cannot form a charge...
1. Currently you are studying threonine synthesis in E. coli. To find genes whose protein products...
1. Currently you are studying threonine synthesis in E. coli. To find genes whose protein products are important for threonine synthesis, you perform a mutagenesis to find mutants that require a source of threonine to grow. (a) Immediately after mutagenizing the bacteria, would you choose to grow the bacteria on rich media or on minimal media? Briefly explain your choice. Rich media. A mutant unable to make a particular amino acid will not be able to grown on media lacking...
1. __________ can cause genes to move from one linkage group to another A. Inversions B....
1. __________ can cause genes to move from one linkage group to another A. Inversions B. Deletions C. UV-light exposure D. Translocations E. Unequal crossing over 2. Transposons that use RNA as an intermediate differ from DNA-only transposons in that the activity of former requires? A. Indirect repeat at one end and direct repeat at the other B. A gene for transposase C. A gene for reverse transcriptase D. A gene for RNA polymerase E. A selectable marker such as...
1. Multiple choice: Self-reactive B cells can be eliminated from the repertoire at several stages of...
1. Multiple choice: Self-reactive B cells can be eliminated from the repertoire at several stages of B cell maturation, including immature B cells that have already emigrated from the bone marrow into the circulation. This latter stage of tolerance induction is critical because: A. Not all self-antigens are expressed or present in the bone marrow during B cell development. B. Immature circulating B cells are more sensitive to antigen stimulation than the developing B cells in the bone marrow. C....
1). What were the justifications given for funding the Human Genome Project? A). Scientific discoveries B)....
1). What were the justifications given for funding the Human Genome Project? A). Scientific discoveries B). Facilitate technological advances C). Understanding and treating human diseases D). Economic impact E). All of the above. 2). What are some of the concerns with using transcriptional Fusion reporter gene constructs to following the expression of the gene of Interest? A ). The reporter gene fused to the gene of Interest may interfere with the proper folding and function of protein product of the...
Please answer all questions if you can. Thank you in advanced! 1. Compare and contrast how...
Please answer all questions if you can. Thank you in advanced! 1. Compare and contrast how secondary structure forms in folded proteins and folded RNA molecules 2. Assume that a bacterial genome contains 5000 genes. Do a “back of the envelope” calculation to estimate the size (number of nucleotides) of the genome of this bacterium. In your answer briefly demonstrate your knowledge of genes. 3. Describe the design of the DNA sequence of an artificial chromosome in a typical eukaryote...
ADVERTISEMENT
Need Online Homework Help?

Get Answers For Free
Most questions answered within 1 hours.

Ask a Question
ADVERTISEMENT