Question

patient is diagnosed with a tumor that has damaged the cells of the posterior pituitary gland....

patient is diagnosed with a tumor that has damaged the cells of the posterior pituitary gland.


Would you expect the patient's urine concentration to be affected? If so, would it increase or decrease?


Would you expect the patient's urine volume to be affected? If so, would it increase or decrease?


For either point above where you said there would be a change, briefly explain


Science   Anatomy-And-Physiology   
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Answer #1

Answer) Posterior pituitary gland secretes a hormone called antidiuretic hormone (also known as vasopressin).

The function of antidiuretic hormone -

-Increases reabsorption of water from distal convoluted tubule (DCT) and collecting duct (CT) of kidneys by increasing permeability of DCT and CT to water (by increasing the pore size through aquaporin-2)

If the cells of the posterior pituitary gland is damaged, then antidiuretic hormone secretion decreases.

So, water reabsorption under influence of antidiuretic hormone is decreased.

Then, more the water present in the urine causing decrease in osmolality i.e decrease in urine concentration.

Urine volume also increases as more the water excreted from the kidneys due to decreased water reabsorption.

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