Question

write every things about the excretion of Codeine drug in human body?

Answer 1

ANSWER: The major metabolic pathway of codeine drug excretion is by glucoronidation which converts codeine to codeine6glucronide, the minor metabolic pathway catalyzed by the enzyme CYP2D6 through N methylation of the codeine to form norcodeine and o methylation to form morphine. The urinary excretion of this codeine drug may be in the form of codeine 70%, norcodeine 10%, morphine 10%, normorphine 4% and bydrocodone 1%. The active form of the drug is morphine which provides the analgesic effect to the patient.