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write about the absorption and distribution of codeine drug in human body

write about the absorption and distribution of codeine drug in human body

Science   Anatomy-And-Physiology   
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Answer #1

Codeine - This is a opioid drug.

This drug is used as analgesic which helps in relieving pain. This codeine is derived from poppy plant called papaver somniferum.

Absorption -

This drug is absorbed in GIT ( gastrointestinal tract). Bioavailability is about 50%. It can be used both in oral and parenteral route. Usage of this codeine drug parenterally leads to transmission of infectious disease such as hepatitis and HIV. This drug is mainly metabolized in liver where it undergoes O- demethylation to form morphine.

Distribution -

Apparent volume of distribution of codeine is about 3-6L/kg. Only about  7-25 % binds to plasma proteins.This drug has extensive distribution in to tissues. It can cross placental barrier and can enters breast milk can leads to teratogenic effects.

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