What effect do you predict that tiger snake (Notechis scutatus) venom would have on muscle contractions of the biventer muscle in response to motor nerve stimulation
In chick biventer cervicis muscle, phrenic nerve diaphragm preparations, venom (3-10 microgram/ mL) produced inhibition of indirect twitches. In the biventer muscle, venom 10 microgram/ mL inhibited responses to acetylcholine (1mmol/L) and carbachol ( 20 micromol/L), but not KCl( 40 mmol/L). The prior administration (10min) of 1 unit/ mL antivenom attenuated the neurotoxic effects of N.scutatus. Administration of 5units/ mL antivenom at t90 partially reversed, over a period of 3 hour, the inhibition of twitches produced by N.scutatus with 41% recovery.
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