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Explain what the impact of mutations in myosin that disrupt ATP binding would have on the...

Explain what the impact of mutations in myosin that disrupt ATP binding would have on the power stroke during muscle contraction. and hydrolysis Skeletal muscle arrangement, ATP binding and correct muscle contractions

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Myosin head without ATP locks tightly on to an actin filament . Binding of ATP to myosin head causes a slight change in the confirmation of the actin binding site. This reduces the affinity of the head for actin and allow it to move along the filament . So, if there is a mutation in the ATP binding site of mysoin then myosin head will be locked with actin filament and muscle will get stiffed and won't allow the power stroke (the force generating changing in shape during which the head regains its original confirmation).

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