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Why does the physician have to be very careful when prescribing non-selective beta blockers to people...

Why does the physician have to be very careful when prescribing non-selective beta blockers to people with asthma? What is it about general beta blockers (specifically) that may make it an unwise prescription?

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When non-selective beta-blockers are administered to people with asthma, bronchoconstriction can occur. Bronchoconstriction occurs when β2adrenoceptors that help bronchodilation are activated by the sympathetic nerves in the bronchioles. So a physician should be very careful when prescribing non-selective beta-blockers due to the contraindications.

Prescribing general beta-blockers (specifically) may make it an unwise prescription because the negative respiratory response to general beta-blockers differs according to the level of cardioselectivity, the dose administered, and the response. It would be dangerous to prescribe a beta-blocker without knowing the cardioselectivity as it is a factor controlling the respiratory response.

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