Question

What is the difference between the muscle relaxants dantrolene and baclofen?

Answer 1

Dantrolene	Baclofen
It is a post synaptic muscle relaxant	It is a CNS depressant
It is administered intravenously	It is administered intrathecally, orally and topically
It decreases excitation contraction	it acts on skeletal muscle
Inhibits calcium ions	doesn't inhibits Ca ions
Metabolised in liver	metabolised by destinationn
Excreted by biliary and renal tracts.	Excreted by renal system
Used in malignant hyperthermia,anesthetic allergies	used on alcohol withdrawal symptoms
Restricted with renal and liver impairments,CVD	used in multiple sclerosis
Children below 5 year can't be given	can't be indicated for stroke and Parkinson patient