Question

J.W. is a 43-years-old male who was diagnosed with a somatotrope adenocarcinoma. As a result, he is diagnosed with acromegaly. Outline of pathological process of this disease. What hormone is altered? What diagnostic tests could be used?

Answer 1

Growth hormone releasing hormone excess secretion from adenoma a pituitary adenoma can stimulate high amounts of growth hormone production. It is also called as an eosinophilic adenoma, somatotroph adenoma and somatotrope. The high amount of growth hormone can leads to acromegaly in adults and gigantism in children.

Diagnostic tests: For identifying somatotroph adenoma histological, biochemical, and imaging studies were performed.

Imaging studies:

Magnetic resonance imaging (MRI) scans

Computed tomography (CT) scan

Biochemical studies:

Medical history and physical exam

Blood and urine tests of hormone levels

Testing for diabetes insipidus

Venous blood sampling

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