Question

Select a common over-the-counter medication and describe its pharmacokinetic and pharmacodynamic properties. Consider factors that may influence pharmacokinetics/pharmacodynamics in different patients such as genetics, gender, age, ethnicity or kidney/liver dysfunction

Answer 1

Ans. Ibuprofen is a common over-the-counter medication.

Pharmacokinetic properties :

Analgesic,antipyretic,and anti -inflamatory actions.

Mechanism of action unknown, thought to inhibit prostaglandin synthesis

pharmacokinetic properties are:

Absorption: 80% of oral dose absorbed from GI tract.

Distribution: Highly protein-bound

Metabolism: Undergoes biotransformation in the liver

Excretion: Excreted mainly in urine,with some biliary excreation.Plasma half-life ranges from 2-4 hours.