Question

What are the strategies to be adopted in the selection antibacterial agents in treating tuberculosis? Provide the mechanism action and their safety profile?

Answer 1

The selection of antituberculosis drug in case the TB patient should be based on the consideration of the combination therapy, considering the resistance of the TB bacteria.

In TB patients the combination therapy of antibacterial agents like Riphampicin, Isoniazid, ethambutol, streptomycin,vancomycin etc. are used under the DOT therapy.

The major strategies to be adopted in the selection antibacterial agents in treating tuberculosis are the selection of drugs in combination on the basis of the t_1/2 as well as the protein binding of the drugs are the bacteria of tuberculosis is highly prone for the resistance.

Most of the drugs used in the tuberculosis are antibacterial antibiotics having the prominent mechanism of action through cell wall synthesis inhibition inhibit the synthesis of mycolic acid, resulting in disruption of the bacterial cell wall like inhibiting the synthesis of mycolic acid by isoniazid leading to the disruption of bacterial cell wall, exerting the antituberculotic action under the antimicrobiac agents category. Also inhibition of  DNA-dependent RNA polymerase by the Riphampicin.

The safety profile of antitubercular agents depends on the lower toxicity profile with improved efficacy by proper selection of the medications under the direct observation therapy. Any Adverse drug reaction sholud be closely observed and reported to the concerned physician and accordingly handelled with time assuring the safety profile of the antitubercolosis medications in the effective manage,ent of tuberculosis in the patients on ground level.