Question

What key properties must an analyte have in order to be quantitated using gas chromatography?

Answer 1

To do gas chromatography of an analyte, the key property associated with analyte is that: it should be possible to vaporize the analyte without decompotion. Which means thermal stability of analyte is of importance. Also, the analyte should not react with the carrier gas. The quantity of analyte is a function of vapour pressure only.

The quantity of analyte can be determined from the area under the peak, as area under a peak is proportional to the amount of analyte present in the chromatograph. Absolute amount of an analyte can be determined with the help of a calibration curve.