Question

a new drug product that has a shelf life of 2.5 years (at room temperature, 25OC). Assuming the drug undergoes 1st‐order degradation, calculate the half‐life for the drug for the degradation reaction at room temperature.

Answer 1

Half life is t_1/2 and shelf life is the time takes to degrade 10% of the product (such as protein or drug).

50% of the product to decay is the half life

10% -------------- 2.5 years

20% -------------- 2 x 2.5 = 5.0 years

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50% --------------- 5 x 2.5 years = 12.5 years

t_1/2 = half-life = 12.5 years

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