4. If we were to use a solvent for an aldol reaction, which of the following would be good/bad candidates? Explain the rational for your answer. a. Acetone b. Methylene chloride c. Ethyl acetate d. Diethylether e. Methanol
a) Acetone BAD because acetone itself is a carbonyl compound and will interfare and produce a mixture of aldol products.
b) methylene chloride BAD because it will react with OH- to produce formal dehyde and again a mixture of products will form
c) Ethyl acetate BAD bacause it generate products of claisen ester condensation in presence of base.
d) Dietyl ether GOOD it does not interfare in aldol condensation.
e) Methanol Good It also doesn't interfare in the reaction.
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