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cite a specific synthetic reaction where protection of the carbonyl group i snecessary to carry out...

cite a specific synthetic reaction where protection of the carbonyl group i snecessary to carry out the process. give the detailed steps and discuss the importance of including the protection step on the procedure.

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Answer #1

One example of protection of carbonyl can be when we are performing an umpolung reaction. Carbonyl carbon is electrophilic in nature but can be converted into a nucleophilic center by protection. Here the carbonyl is first protected with 1,3-dithiol to give dithiane derrivative. The carbonyl carbon center now can react with a base as BuLi, deprotonation at carbon center occurs to form carbanion which can then react with an electrophile. The strategy is shown below.

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